the effect of green tea extract on reproductive improvement in estradiol valerate-induced polycystic ovary polycystic ovarian syndrome in rat

Authors

mohammad nabiuni 1.3. department of cell and molecular biology, faculty of biological sciences, kharazmi university, tehran, iran.

habibeh ghafurniyan department of cell and molecular biology, faculty of biological sciences, kharazmi university, tehran, iran.

mahnaz azarnia department of cell and molecular biology, faculty of biological sciences, kharazmi university, tehran, iran.

latifeh karimzadeh department of cell and molecular biology, faculty of biological sciences, kharazmi university, tehran, iran.

abstract

polycystic ovary syndrome (pcos) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. green tea is a potent antioxidant since it containscatechins. in this study, the effect of hydro-alcoholic green tea extract on pcos rats was examined.for pcos induction, 96 mature wistar rats were given estradiol valerate. after 60 days, therats were divided into four groups including pcos group and three experimental groups, whichwere given 50, 100 and 200 mg/kg bw green tea extract 10 days, intraperitoneally. the serumconcentration level of fsh, lh, testosterone and insulin were measured using elisa method,while the serum concentration level of glucose was measured using glucose oxidase methods.insulin resistance was calculated using homa-ir formulation. the data were analyzed usingthe one-way anova method considering p<005/ level of significance.there were a significant reduction in lh serum level, body and ovarian weight between thegreen tea extract treated-groups compare to pcos. moreover, a significant reduction in insulinresistance index was seen in the treatment groups related to pcos. histomorphometric studiesalso showed the significant changes in the number of follicles and theca layer thickness.these changes demonstrated a marked improvement in the symptoms of pcos which maybe due to green tea effects on oxidative stress pathways. green tea can be considered as apotentially effective drug for treatment of pcos, insulin resistance and type ii diabetes.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat

Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...

full text

The Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat

Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...

full text

The Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovarian Syndrome in Rat

Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which the level of oxidative elements in blood rises. Green tea is a potent antioxidant since it contains catechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined. For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, the rats were divided int...

full text

Histochemical study of estradiol valerate-induced polycystic ovary syndrome in the rat

For the present study, and follow-up of histochemical changes in estradiol valerate-induced polycysticovary syndrome (PCOS), 48 virgin 90-day-old female rats were used. The rats were divided into thetreatment and control groups. For each rat of the treatment group, 4 mg estradiol valerate was injectedthrough intramuscular route for the induction of PCOS. The control group was taken the same amo...

full text

Changes of The Uterine Tissue in Rats With Polycystic Ovary Syndrome Induced by Estradiol Valerate

Objective : Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders that can lead to irregular menstrual cycles and hyperandrogenism. Reduced levels of progesterone and increased estrogen in these women can perpetually stimulate the endometrial tissue of the uterus. In this study, the effect of PCOS induction was studied using estradiol valerate. MaterialsAndMethods Adult ...

full text

histochemical study of estradiol valerate-induced polycystic ovary syndrome in the rat

for the present study, and follow-up of histochemical changes in estradiol valerate-induced polycysticovary syndrome (pcos), 48 virgin 90-day-old female rats were used. the rats were divided into thetreatment and control groups. for each rat of the treatment group, 4 mg estradiol valerate was injectedthrough intramuscular route for the induction of pcos. the control group was taken the same amo...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of pharmaceutical research

جلد ۱۴، شماره ۴، صفحات ۱۲۱۵-۱۲۲۳

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023